Nanoliposome for liver-targeting RNA interference delivery

Abstract: The present invention relates to a nanoliposome for delivering a factor for inhibiting gene expression specific to a hepatic tissue. The nanoliposome comprises a compound represented by chemical formula 1, and is modified with galactose residues. The nanoliposome of the present invention increases silencing efficiency of a target substance in liver, and reduces hepatotoxicity generated during systematic administration. Thus, the nanoliposome efficiently delivers the target substance to liver, and thus can be used as a therapeutic agent for hepatitis C.
Patent Number: KR101685304(B1)
Public Date:
Inventor: CHO SEUNG WOO [KR]; PARK HYUN JI [KR]
Applicant: INDUSTRY-ACADEMIC COOP FOUND YONSEI UNIV [KR]
Application Number: KR20150139007 20151002Global Dossier
Application Date:
Priority Number: KR20150139007 20151002
International Classification: A61K9/127
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