COMPOSITIONS FOR BACTERIAL MEDIATED GENE SILENCING AND METHODS OF USING SAME

Abstract: Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating cancer of cell proliferative disorders. The bacterium includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells.
Patent Number: US2016369282(A1)
Public Date:
Inventor: LI CHIANG [US]; FRUEHAUF JOHANNES H [US]; XIANG SHUANGLIN [US]
Applicant: MARINA BIOTECH INC [US]
Application Number: US201514875751 20151006Global Dossier
Application Date:
Priority Number: US201514875751 20151006;US201113196436 20110802;US20070793429 20071120;WO2005US45513 20051216;US20050651238P 20050208;US20040637277P 20041217
International Classification: A61K35/74; C12N15/113
Cooperative Classification: A61K35/74; C12N15/111; C12N15/113; C12N15/1135; C12N15/1137; C12N15/1138; C12N15/8218; C12N2310/111;
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